Scientific Program
Scientific program
Wednesday 17th November
13:45 - 14:00 : Opening ceremony
Scientific director of Cancéropôle Grand Sud-Ouest
14:00 - 16:00 : Plenary session
- Liquid biopsies
Chairs: Anne-Marie GUE & Fabrice LALLOUE
- KEYNOTE SPEAKER (virtual): Caroline DIVE, Cancer Biomarker Centre, CRUK Manchester Institute, University of Manchester (United Kingdom) - Liquid biopsies to support better treatment for small cell lung cancer
- Sandrine DABERNAT, Biotherapy for genetic diseases, inflammation and cancer (Bordeaux) - Extracellular vesicle liquid biopsy: the next generation cancer biomarker ?
- Camille DANTZER, Bordeaux Research in Translational Oncology - Mutated b-catenin regulates extracellular vesicles machinery in hepatocellular carcinoma
- KEYNOTE SPEAKER: Valérie TALY, Centre de Recherche des Cordeliers, Inserm U1138, CNRS SNC5096 (Paris) - Tracking circulating tumor DNA for cancer patient follow-up
17:00 - 18:30 : Parallel sessions organized by Cancéropôle GSO Axes
- Ions channels & Cancer / Axis 1 session
Chair: Bruno CONSTANTIN
- KEYNOTE SPEAKER: Albrecht SCHWAB, Institute of Physiology II, Münster (Germany) - The role of KCa3.1 channels in non-small cell lung cancer
- Bruno CONSTANTIN, Laboratoire STIM - CNRS ERL 7003 - EA 7349 (Poitiers) - Calcium signaling in cancer stem cells
- David MOREAU, École des Mines de Saint-Étienne - Manipulation of ionic channels and calcium signaling in glioblastoma with infrared radiation
- Catherine LECLERC, Molecular, cellular and developmental biology Unit, CBI-MCD (Toulouse) - Quiescence status of glioblastoma stem-like cells involves remodelling of Ca2+ signalling and mitochondrial shape
- Translational research, from biology to the clinic : Flash Posters / Axis 3 session
Chair: Majid KHATIB
- Alexandra FAUVRE, Montpellier Cancer Research Institute - Platinum-based chemotherapy induce inflammation via a non-canonical STING pathway dependent on ATM activation
- Alexia FRANCOIS, Angiogenesis and Cancer Microenvironment Laboratory (Bordeaux) - Proteolytic protein repression mediates tumor T cells infiltration and anti-tumoral immune response: Drug-repurposing approach
- Amandine AMALRIC, Institute for Functional Genomics (Montpellier) - “Epitranscriptomics”: a promising source of biomarkers for personalized medicine
- Céline HERVIEU, CAPTuR (Limoges) - Colorectal cancer stem cells respond differently to chemotherapies depending on their original location
- Elsa FRISTOT, Structural Biochemistry Center (Montpellier) - Programming lactic acid bacteria for colorectal cancer therapy
- Jean DESCARPENTRIE, Angiogenesis and Cancer Microenvironment Laboratory (Bordeaux) - Repression of liver colorectal metastasis by the naturally occurring inhibitor of Furin (ppFurin)
- Johanna MARINES, AZELEAD (Montpellier) - Modelling 3D tumour microenvironment in vivo using live imaging technique : a tool to predict cancer fate
- Kévin BIGOT, Montpellier Cancer Research Institute - New Imidazo[1,2-a]quinoxalines compounds for Pancreatic Ductal Adenocarcinoma treatment : mechanism of action and target identification
- Marine BRUCIAMACCHIE, Montpellier Cancer Research Institute - Association of oxaliplatin-based chemotherapy and ATR inhibitor in pancreatic cancer
- Soha SALLOUM, Institute of Human Genetics (Montpellier) - Characterization of b-catenin translation factories
- Zeinab TARHINI, Limoges University - The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus
- Health technologies / Axis 5 session
Chair: Anne-Marie GUE
- EMERGENCE CALLS - Computational biology and models for Cancer
- Sylvain CUSSAT-BLANC, Institut de Recherche en Informatique de Toulouse - ISiCell : a web-oriented platform to model cellular processes
- Ovidiu RADULESCU, Laboratory of Pathogen Host Interactions (Montpellier) - Computational Models of Heterogeneity in Melanoma: Designing Therapies and Predicting Outcomes
- 5 selected talks for "Ma techno en 180 secondes" (flash posters toutes technologies)
- Malvina MARKU, Cancer Research Center of Toulouse - On the dynamics of TAM formation in Chronic Lymphocytic Leukaemia: a multi-scale approach
- Chloé BESSIERE, Institute for Regenerative Medicine and Biotherapy (Montpellier) - Towards a novel framework for large scale RNAseq data analysis in human health
- Alexia BRUNEL, Cancer Research Center of Toulouse - Bioinformatical analysis of tumor cell with stroma crosstalk that impact aggressiveness of pancreatic ductal adenocarcinoma
- Elisa LAMBERT, XLim (Limoges) - Microfluidic Lab-On-Chip for UHF-Dielectrophoresis Discrimination of Glioblastoma Undifferentiated cells
- Justine JOURNAUX, Cancer Research Center of Toulouse - Nanotherapy of pancreatic adenocarcinoma by targeted magnetic hyperthermia: efficacy and mechanisms
Thursday 18th November
08:30 - 10:05 : Plenary session
- Myeloid cells in cancer
Chairs: Mary POUPOT & Nicolas LARMONIER
- KEYNOTE SPEAKER: Antonio SICA, University of Piemonte Orientale 'A. Avogadro' (Novara) and Humanitas Clinical and Research Center, Milan (Italy) - Therapeutic targeting of myelopoiesis in cancer
- Frédéric LAGARRIGUE, Institute of Pharmacology and Structural Biology (Toulouse) - Integrin signaling in tumor-associated macrophages
- Julien FAGET, Montpellier Cancer Research Institute - Lessons from the remote alteration of granulopoiesis in NSCLC: what is neutrophil homeostasis telling us on immune checkpoint blockade ?
- Céline BLAYE, Institut Bergonié and ImmunoConcept Lab (Bordeaux) - The tumor-promoting myeloid landscape in breast cancers
11:00 - 12:45 : Plenary session
- Preneoplasia & early dissemination
Chairs: Julie GUILLERMET-GUIBERT & David SANTAMARIA
- KEYNOTE SPEAKER (virtual): Daniel MUÑOZ-ESPÍN, CRUK Cambridge Centre Early Detection Programme, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge (United Kingdom) - Impact of cellular senescence in lung precancerous lesions: senotherapeutic opportunities
- Julie GUILLERMET-GUIBERT, Cancer Research Center of Toulouse - Role of extrinsic factors in cancer initiation: importance of the stressed niche in pancreatic cancer
- Zeinab HOMAYED, Institute for Functional Genomics (Montpellier) - Unravelling the role of early dissemination in colorectal cancer
- Dimitri HAMEL, Digestive Health Research Institute (Toulouse) - Epithelio-stromal relationships in physiology & IBD: osteopontin, a key factor for epithelial regeneration and tumor initiation ?
- Hamid-Reza REZVANI, Biotherapy for genetic diseases, inflammation and cancer (Bordeaux) - Metabolic and immune features as predictive biomarkers of risk stratification of skin carcinoma
14:15 - 16:05 : Parallel sessions organized by Cancéropôle GSO Axes
- Cell signaling and therapeutic targets / Axis 1 session
Chair: Violaine MOREAU & Julie PANNEQUIN
- Damien GREGOIRE, Institute of Molecular Genetics of Montpellier - Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of primary and metastatic hepatocellular carcinoma
- Lucile BANSARD, Institute for Functionals Genomics (Montpellier) - JMV7048, First-in-class PROTAC degrader of PXR
- KEYNOTE SPEAKER: David SANTAMARIA, Inserm U1218 Action (Bordeaux) - Novel mechanisms controlling KRAS oncogenic output: impact on tumour fitness and cancer vulnerabilities
- Coralie CAYRON, Cancer Research Center of Toulouse - PI3K signaling and tumoral metabolism in pancreatic cancer
- Thomas NAVES, CAPTuR (Limoges) - Sortilin exhibits tumor suppressor-like activity by limiting EGFR function
- Marcin DOMAGALA, Cancer Research Center of Toulouse - Characterization of a novel monoclonal antibody targeting tumor-associated macrophages
- Genome dynamics and cancer / Axis 2 session
Chair: Gaëlle LEGUBE & Malik LUTZMANN
- KEYNOTE SPEAKER (virtual): Joanna MORRIS, Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, University of Birmingham (United Kingdom) - Back-up pathways that support BRCA1 deficient cells
- Sébastien BRITTON, Institute of Pharmacology and Structural Biology (Toulouse) - BRCA1 prevents R-loop-associated centromeric instability
- Israa AL JAMAL, CRIBL (Limoges) - IgH Locus Suicide Recombination (LSR) in Chronic Lymphocytic Leukemia (CLL): Prognosis Indicator ?
- Yvan CANITROT, Molecular, cellular and developmental biology Unit, CBI-MCD (Toulouse) - Control of Homology directed repair of DNA double strand breaks by the KDM8 histone demethylase
- Francesco CALZAFERRI, Institut des Biomolécules Max Mousseron (Montpellier) - New strategies to target DNA methylation: from the discovery of novel DNMT inhibitors to the identification of novel epigenetic targets
- Vera PANCALDI, Cancer Research Center of Toulouse - Network approaches to dissect the epigenome-phenotype connection in immune cell
- Patients-partenaire-formateur-co-chercheur : des savoirs expérientiels légitimes ? / session Axe 4
Modération:
- 1 ORATEUR INVITE: Arnaud HALLOY, Université de Nice - Savoirs expérientiels et partenariat patient : une alliance indispensable | Intervention à distance
- Frédéric BOUHIER, Chargé de mission Société Française de Santé publique - VIH/Sida et Empowerment : « Quels enseignements pour la mobilisation des patients en cancérologie ? »
- Sabine DUTHEIL, Patiente partenaire Bordeaux - Le cancer du sein, une maladie chronique pas (tout à fait) comme les autres?
17:00 - 18:30 : Plenary session and session Axe 4
- Research in Melanoma
Chair:
- Anne MONTFORT, Cancer Research Center of Toulouse - Combining TNF inhibitors to anti-PD-1 and anti-CTLA-4 for the treatment of advanced melanoma patients
- Xavier ORLIK, ONERA (Toulouse) - Real time in vivo observation of the human skin microvascularization
- Léa DOUSSET, Biotherapy for genetic diseases, inflammation and cancer (Bordeaux) - Vitiligo under PD-1 inhibitors for melanoma patients: what's new and how we can go further ?
- KEYNOTE SPEAKER : Daniel PEEPER, The Netherlands Cancer Institute, Amsterdam (The Netherlands) - Rational concepts for tumor & immune cell therapy combinations
- Le patient-partenaire en institution
Introduction et modération: Béatrice Jacques
- Sabine DUTHEIL, Patient partenaire (Bordeaux), Delphine GARBAY, Oncologue (Bordeaux) et Hortense FRANCK, Oncoradiothérapeute (Bordeaux) - Patiente Partenaire au SEIN d’une équipe d’oncologie : un dispositif innovant
- Juliane LAMELOT-PELARD, Université de Nantes, Margaux LEBORGNE, Université de Nantes et Bertrand PORRO, Université de Nantes, Angers et Montpellier - Accompagnement des femmes diagnostiquées d'un premier cancer du sein par une patiente-partenaire: Quels bénéfices à moyen et long termes ? Une étude comparative
- Johanne VASSELLIER, ARS Nouvelle Aquitaine - Une expérimentation innovante : le salariat de patient partenaire en cancérologie
Friday 19th November
08:30 - 10:15 : Parallel sessions organized by Cancéropôle GSO Axes
- Poor prognosis Cancers: Brain tumors / Axis 3 session
Chair: Norbert BAKALARA & Fabrice LALLOUE
- Thomas DAUBON, Institute for cellular biochemistry and genetics (Bordeaux) - Glioblastoma Metabolic Symbiosis: When Lactate Takes The Lead
- Charles DUPIN, Biotherapy of genetic diseases, inflammatory disorders and cancers (Bordeaux) - Glioblastoma, radiotherapy and 5-AminoLevulinic Acid: a dead end ?
- Gabriel MARSERES, Immunology from concept and experiments to translation (Bordeaux) - Targeting glioblastoma with in vitro amplified Vd2neg gd T cells: preclinical study
- Alexandra GARANCHER, Montpellier Cancer Research Institute - Understanding the immune microenvironment to improve immunotherapy for pediatric brain tumors
- Jean-Philippe HUGNOT, Institute for Functional Genomics (Montpellier) - Insight on the tumoral cell diversity, their formation and proliferation in IDH1-mutant diffuse low brain gliomas: a key role for Notch1 signaling
- Extracellular matrix & cancer / Axis 5 session
Chair: Christine BEZOMBES & Anne-Marie GUE
- KEYNOTE SPEAKER: Audrey FERRAND, Digestive Health Research Institute (Toulouse) - Extracellular Matrix Mechanical Properties and Regulation of the Intestinal Stem Cells: When Mechanics Control Fate
- Christine VARON, Bordeaux Research in Translational Oncology - The bacterial genotoxin, cytolethal distending toxin, modulates cell differentiation and elicits epithelial to mesenchymal transition
- Laure GIBOT, Molecular Interactions and Chemical and Photochemical reactivities (Toulouse) - Electric fields as powerful tools to transiently modulate cutaneous extracellular matrix
- Clément AUGER, CAPTuR (Limoges) - Using nanoparticle tracking analysis (NTA) for appreciation of up and down extracellular vesicle secretion
- Léa NORMAND, Bordeaux Research in Translational Oncology - Tumor cells-released tracks promote cell migration on type I collagen
- Le patient formateur / session Axe 4
Introduction et modération: Béatrice Jacques
- Olivia GROSS, LEPS UR 3412, Université Sorbonne Paris Nord - L'expérience de Bobigny | Intervention à distance
- Marie-France KOLTES, Institut des métiers de la santé et Patrick LARTIGUET, aidant partenaire formateur (Bordeaux) - Du paternalisme médical au partenariat en santé : accompagner le changement auprès des établissements de formation des professionnels de santé
- Sandra ALLAIRE de la FUENTE, patiente partenaire en oncologie (Bordeaux) - Du témoignage bénévole à la co-construction d’une séquence pédagogique rémunérée
- Guy KANTOR , ligue contre le cancer en Aquitaine - Lancement d'un dispositif de formation par les patients au sein de la ligue contre le cancer de Gironde | Intervention à distance
11:00 - 12:30: Plenary session and session Axe 4
- Poor prognosis Cancers: Pancreatic cancer
Chair: Marlène DUFRESNE & Véronique GIGOUX
- KEYNOTE SPEAKERs: Núria MALATS & Francisco X. REAL, CNIO, Madrid (Spain) - Learning from biology: The challenge of pancreatic cancer prevention
- Guillaume TOSATO, Montpellier Cancer Research Institute - Discovery of Soluble Pancreatic Cancer Biomarkers Using Innovative Clinical Proteomics and Statistical Learning
- Yvan MARTINEAU, Cancer Research Center of Toulouse - Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer
- Pierre CORDELIER, Cancer Research Center of Toulouse - Targeting cancer cells with basal-like, mesenchymal phenotype with oncolytic virus to inhibit the growth of pancreatic cancer
- Corinne BOUSQUET, Cancer Research Center of Toulouse - Towards the identification of Cancer-Associated Fibroblast signaling underlying pancreatic cancer aggressiveness
- Le patient co-chercheur / session Axe 4
Introduction et modération: Béatrice Jacques
- Lise MOLIMARD et Nathalie CAPLET, SIRIC Brio - Implication des patients en recherche : retours d'expériences et réflexions sur différentes modalités
- Julien BIAUDET, Cancéropôle CLARA et Robert Merle, patient partenaire (Lyon) - Construire un appel à projets avec et pour les patients : retour d’expérience du Cancéropôle CLARA
- Pascal RAGOUET, Centre Emile Durkheim (Bordeaux) - Recherche profane et autothérapie. Quelques pistes sur le concept de recherche translationnelle centrée patient
