Scientific Program
Scientific program
Wednesday 20nd November
13:45 - 14:00 : Opening ceremony - Oncosphere presentation
Muriel MATHONNET, Scientific director of Cancéropôle Grand Sud-Ouest
Pierre SOUBEYRAN, Inserm Actions for onCogenesis understanding and Target Identification in Oncology, Bergonié Institute (Bordeaux)
14:00 - 16:00 : Plenary session
- Translational research: from biology to clinics
Chairs: Julie PANNEQUIN and Majid KHATIB
- KEYNOTE SPEAKER: Thomas HELLEDAY, Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield (United Kingdom) - Targeting DNA repair: from basic biology to clinical trials
- (Not) lost in translation: gene therapy for pancreatic cancer - Pierre CORDELIER, Cancer Research Center of Toulouse
- Smart-devices for the detection of circulating cancer biomarkers in clinical routine - Aline CERF, LAAS-CNRS (Toulouse)
- Mass spectrometry in clinical practice using hepatocellular adenomas as a proof of concept - Frederic SALTEL, Bordeaux Research in Translational Oncology
- Glycosylation and cancer: the phostines window - Norbert BAKALARA, Institute for Neurosciences of Montpellier
17:00 - 18:30 : Parallel sessions organized by Cancéropôle GSO Axes
- Post-translational modifications and cancer / Axis 1 & Axis 2 session
Chairs: Olivier COUX
- KEYNOTE SPEAKER: Sylvie URBE, Institute of Translational Medicine, University of Liverpool (United Kingdom) - Deubiquitylases (DUBs): druggable regulators of protein and organelle homeostasis
- Targeting the ubiquitin-like molecule Nedd8 for therapeutic intervention - Dimitris XIRODIMAS, Center for Biochemical and Macromolecular Research (Montpellier)
- Hydrogen sulfide (H2S) signals through protein persulfidation - Milos FILIPOVIC, Cellular Biochemistry and Genetics Institute (Bordeaux)
- ER-resident oxidoreductase surfaces to promote liver tumor invasiveness - Manon ROS, Bordeaux Research in Translational Oncology & Institute of Molecular and Cell Biology (Bordeaux)
- The E3 ubiquitin ligase ASB2α in T helper 2 cells negatively regulates antitumor immunity in colorectal cancer - Pierre LUTZ, Institute of Pharmacology and Structural Biology (Toulouse)
- Education thérapeutique / session Axe 4
Modération: Florence SORDES
- ORATEUR INVITE: Sandrine ROUSSEL, Université Catholique de Louvain (Belgique): Education thérapeutique : constats, défis & applications en cancérologie
- Programme ETP "GYN and Co LR": Evaluation d'une prise en charge précoce des troubles sexuels et fonctionnels pelviens chez les patientes traitées par curiethérapie utérovaginale ou intravaginale - Anne STOEBNER, Département des soins de support, ICM (Montpellier)
- 3 communications sélectionnées
- Efficacité d'un programme d'ETP pour patients sous anticancéreux oraux - Alice DHELLEMMES, laboratoire CERPPS, Toulouse
- Recrutement d'une patiente diplômée dans le cadre d'une UTEP rattachée à un Centre le lutte contre le cancer - Emmanuelle ARFE, IUCT Oncopôle, Toulouse
- Effets de la réduction du stress basée sur la pleine conscience sur "l'empowerment" du patient atteint de cancer et sur la peur de la récidive - Marion Barrault, Institut Bergonié, Bordeaux
- Health technologies / Axis 5 session
Chairs: Hervé SEZNEC & Marie-Pierre ROLS
- EMERGENT PROJECTS
- Frédéric FRISCOURT, European Institute of Chemistry and Biology (Bordeaux) - Towards the Selective Tagging of the Sialome for Imaging Cancer Cells - A Chemical Biology Tale
- Véronique GIGOUX, Laboratory of Physics and Chemistry of Nano-Objects (Toulouse) - Targeted magnetic nanoparticles remotely induced mechanical destruction of tumor microenvironment through rotating magnetic field
- 5 selected talks for "Ma techno en 180 secondes" (flash posters toutes technologies)
- Pulsed electric fields as key element overcoming cold-atmospheric plasma limits in cancer therapy - Elena GRISETI, Laplace Lab & Institute of Pharmacology and Structural Biology (Toulouse)
- Photodynamic therapy activity of new porphyrin-xylan-coated silica nanoparticles in a human colorectal cancer in vivo model - Ludovic BRETIN, Peirene Lab, University (Limoges)
- Detection of lipid droplets by MCARS microspectroscopy in cells expressing TrkB - Tiffany GUERENNE-DEL BEN, Peirene Lab, University (Limoges)
- Imaging of cancer cell death induced by magnetic hyperthermia - Pauline JEANJEAN, IMOTION, University (Bordeaux)
- Development of remotely controllable polymersomes for image guided drug-delivery - Olivier SANDRE, Organic Polymers Chemistry Laboratory (Bordeaux)
- Numerical investigation of the role of mechanical constraints on the growth of 3D tumour cells aggregates - Vincent LE MAOUT, Institute of Mechanical Engineering (Bordeaux)
Thursday 21st November
08:30 - 10:00 : Plenary session and session Axe 4
- Mechanical constraints in oncological processes
Chairs: Malik LUTZMANN
- KEYNOTE SPEAKER: Matthieu PIEL, Curie Institute (Paris) - Mechanisms and consequences of large nuclear deformation: from microchannels to breast tumors
- A new way to escape: how structural centrosome aberrations promote invasive behaviors of epithelial cells - Olivier GANIER, Institute of Human Genetics (Montpellier)
- Making, watching and stressing tumor organoids in 3D - Pierre NASSOY, Photonics, Numeric and Nanosciences Laboratory & Institut Optique Graduate School (Bordeaux)
- MAGI1 suppresses luminal breast cancer through its interaction with AMOTs and the regulation of YAP signaling - Alexandre DJIANE, Cancer Research Institute of Montpellier (Montpellier)
- Recherche interventionnelle (1)
Modération: Louise POTVIN
- ORATRICE INVITEE: Louise POTVIN, École de santé publique, Université de Montréal, (Canada) - La recherche interventionnelle: science des solutions.
- Table-ronde : Linda Cambon (UMR1212 Bordeaux Population Health, Bordeaux), Florence Cousson-Gélie (département Epidaure et laboratoire Epsylon, Montpellier), Cyrille Delpierre (UMR 1027 Epidémiologie et analyses en santé publique: risques, maladie chronique et handicap, équipe Equity, Toulouse), Pierre Ingrand (Registre des cancers Poitou Charentes, INSERM CIC 1402, Poitiers), Grégory Ninot (plateforme CEPS et laboratoire Epsylon, Montpellier), Philippe Terral (CRESCO: Centre de recherches sciences sociales sports et corps , Toulouse)
11:00 - 12:45 : Plenary session and session Axe 4
- Chemical biology and cancer
Chair: Sébastien BRITTON
- KEYNOTE SPEAKER: Raphaël RODRIGUEZ, Curie Institute (Paris) - Prevalent roles of iron in cancer
- Alternative therapeutic technologies to target undruggable proteins - Muriel AMBLARD, Max Mousseron Biomolecules Institute (Montpellier)
- Programming molecules for cancer therapy - Sébastien PAPOT, Institute of Chemistry of Materials and Media of Poitiers
- Targeting cancer stem cells with antibiotics - Hélène GUILLORIT, Institute for Functional Genomics (Montpellier)
- Oligo-urea foldamers used as tools to induce apoptosis: Study case of the death receptor DR5/TRAIL-R2 - Benoit ODAERT, Institute of Chemistry and Biology of Membranes and Nano-objects (Bordeaux)
- Recherche interventionnelle (2)
Modération: Florence COUSSON-GELIE
- ORATEUR INVITE: Antoine DEUTSCH, Institut National du Cancer (Paris) - les enjeux du déploiement national d’intervention probante
- 3 communications sélectionnées
- Transformer l'essai de l'expertise en recherche partenariale et interventionnelle : le rôle des plateformes d'expertise universitaire en Santé Publique - Charlie MARQUIS, IFERISS, Toulouse
- Collaboration de recherche en ETP : retour d'expérience sur les freins et leviers - Emilie GABORIT, IFERISS Toulouse
- Pour des interventions justes nécessaires : élaboration d'un outil d'aide au repérage et de prise en charge du retour et/ou maintien en emploi pour des femmes diagnostiquées d'un cancer du sein. Projet REWORK-BC (SIRIC ILIAD) - Bertrand PORRO, Université d'Angers et université Paul Valéry, Montpellier
14:15 - 15:45 : Parallel sessions organized by Cancéropôle GSO Axes
- Genome dynamics and cancer / Axis 2 session
Chair: Malik LUTZMANN
- KEYNOTE SPEAKER: Raphaël CECCALDI, Curie Institute (Paris) - How BRCA-deficient tumors ensure DNA replication and repair
- New synthetic lethality approaches targeting DNA safeguard pathways and the mitochondrial step of nucleotide neosynthesis (pyrimidine) in breast cancer - Stéphanie ARNOULD, Cancer Research Institute of Montpellier
- Generation of cells resistant to tyrosine kinase inhibitors in chronic myeloid leukemia by a genome editing technique - François-Xavier MAHON, CLCC Bordeaux & UMR1218 ACTION (Bordeaux)
- Spatial distribution of FTO adjusts colorectal cancer stem-like properties through RNA modification - Amandine BASTIDE, Institute for Functional Genomics (Montpellier)
- Translational Research, from biology to clinics / Axis 3 session
Chairs : Fabrice LALLOUE & Majid KHATIB
- EMERGENT PROJECTS :
- Resistance of Melanoma to Immune Checkpoint Inhibitors is Overcome by Targeting the Sphingosine Kinase 1 - Céline COLACIOS, Toulouse Cancer Research Centre
- Definition of new biomarkers of aggressiveness in glioma - Elise DELUCHE, Limoges University Hospital
- API-K PROJECTS :
- Mutations of the B-cell receptor pathway confer chemoresistance in primary cutaneous diffuse large B-cell lymphoma leg-type - Audrey GROS, Bordeaux Research in Translational Oncology and Bordeaux University Hospital
- FLASH POSTERS :
- The endoplasmic reticulum resident-AGR2 protein : a novel secreted biomarker with pro-oncogenic properties - Delphine FESSART, Actions for onCogenesis understanding and Target Identification in Oncology
- Tumor antigen-specific CD8 T cells identified by TIM-3 expression predict response to PD-1 blockade in head and neck cancer - Camille-Charlotte BALANÇA, Cancer Research Center of Toulouse
- Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer, through reduced expression of SDHC - Gro ROSLAND, Department of Biomedicine and department of Clinical Science, University of Bergen (Norway)
- Towards Precision Medicine using Tumor-adapted H-1PV oncolytic virus in Preclinical Models of PDAC - Pierre CORDELIER, Toulouse Cancer Research Centre
- Targeting proteolytic notch activation inhibits PD-1 expression and improves cytotoxic T lymphocytes (CTL) cytotoxicity against MSI and MSS tumor cells and enhances tumor-infiltrated CTLs and tumor regression - Fabienne SOULET, Angiogenesis and Cancer Microenvironment Laboratory - ACML and Bordeaux University
- Preclinical xenograft and culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneity - Sandrine POGLIO, Bordeaux Research in Translational Oncology
- Expression by immunohistochemistry of Anaplastic Lymphoma Kinase (ALK) in Glioblastoma Multiforme : Foreshadow of clinical implications (GLIMAL1 study) - Labib EL HAJJ, Poitiers University Hospital
- KEYNOTE SPEAKER: Targeting Apelin cleavage sites for colorectal cancer treatment - Géraldine SIEGFRIED, Angiogenesis and Cancer Microenvironment Laboratory - ACML (Bordeaux)
- Ethique et prévention: aspects individuels et collectifs / session Axe 4
Modération: Annie SASCO - Présentation de la session >>
- ORATRICE INVITEE : Emmanuelle RIAL SEBBAG, BIOETHICS (Toulouse) - Penser l'éthique au delà de l'individu: pour une éthique collective
- Faiza BESSAOUD, Montpellier Cancer Institute, Effet du dépistage basé sur le PSA sur la mortalité par cancer de la prostate: résultats dans deux départements avec registre de cancer
- Florian MARTINET, Epidémiologie et analyses en santé publique: risques, maladies chroniques et handicaps (Toulouse), Etat des lieux de l'information relative à l'oncofertilité pour les femmes jeunes atteintes d'un cancer du sein en ex-région Midi-Pyrénées : approches épidémiologique et éthique
- Silviane DARQUY, Bordeaux Population Health, Utilisation du diagnostic prénatal dans le contexte d'une maladie génétique à révélation tardive: Points de vue croisés entre patients et professionnels
16:45 - 18:15 : Plenary session
- Translational research: from biology to surgery
Chair: Muriel MATHONNET
- KEYNOTE SPEAKER: Patrick PESSAUX, Strasbourg University Hospital - Planification-simulation-navigation: toward a precise surgery
- Digital innovations in liver surgery: toward the digital tween - Eric VIBERT, APHP - Paul Brousse Hospital (Villejuif)
- From the bench to the bedside : development of SGM-101, a CEA-targeting agent for intraoperative fluorescence imaging of colorectal carcinoma - Françoise CAILLER, SurgiMab (Montpellier)
18:15 - 19:00 : Plenary session
- Ethics in cancer research
Chair: Julie PANNEQUIN
- KEYNOTE SPEAKER: Hervé CHNEIWEISS, Inserm Ethics Committee President & Hed of the Neuroscience Department (Paris) - What are the current challenging ethical issues in oncology research ?
Friday 22nd November
08:30 - 10:15 : Parallel sessions organized by Cancéropôle GSO Axes
- Microenvironment & Invasion / Axis 1 session
Chair: Violaine MOREAU
- KEYNOTE SPEAKER: Martin HUMPHRIES, Wellcome Center for Cell-Matrix Research, University of Manchester (UK) - Mechanisms of extracellular rigidity sensing via the adhesion nexus
- Glioblastoma metabolism and microenvironment: putting tumor back in context - Thomas DAUBON, Angiogenesis and Cancer Microenvironment Laboratory - ACML (Bordeaux)
- Mechanosensitive TRP channels push cancer cells invasion and metastasis formation - Aubin PENNA, Signalisation and Membrane Ionic Transports Laboratory - STIM (Poitiers)
- Role of Leukaemia Inhibitory Factor (LIF) on the tumorigenic properties of Cancer Stem Cells in gastric adenocarcinoma - Lornella SEENEEVASSEN, Bordeaux Research in Translational Oncology (Bordeaux)
- Regulation of tumor-derived DNA potential to activate anti-tumor immune responses by extracellular DNases - Vanja SISIRAK, ImmunoConcEpt : Immunology from Concept and Experiments to Translation (Bordeaux)
- Mathematical modeling for therapy response prediction / Axis 3 & Axis 5 session
Chairs: Romain LARIVE & Majid KHATIB
- KEYNOTE SPEAKER: Rosa HERNANSAIZ BALLESTEROS, Institute for Computational Biomedicine (Heidelberg, Germany) - Multi-omics contextualisation of signalling pathways to identify drug targets and essential genes in cancer
- Early evaluation of cancer treatments using modeling and AI - Olivier SAUT, Institute for Research in Computer Science and Automation (Bordeaux)
- Tumor microenvironment cellular network inference and analysis from bulk and single cell transcriptomes - Jacques COLINGE, Cancer Research Institute of Montpellier
- Radio-genomics approach for therapy response prediction - Thierry COLIN, Sophia Genetics (Bordeaux)
11:00 - 12:30: Plenary Session
- Research in thoracic oncology
Chair: David SANTAMARIA
- KEYNOTE SPEAKER: Mariano BARBACID, Spanish National Cancer Research Center - CNIO (Madrid, Spain) - Targeting K-RAS mutant lung tumors: an unmet medical need
- Understanding and overcoming resistance to targeted therapy in lung cancer - Julien MAZIERES, Toulouse Oncopole Cancer University Institute - IUCT-O (Toulouse)
- Targeting acquired vulnerabilities in drug resistant BRAFV600E lung adenocarcinoma patients - Marie-Julie NOKIN, Actions for onCogenesis understanding and Target Identification in Oncology (Bordeaux)
- Notch Inhibition Overcomes Resistance to Tyrosine Kinase Inhibitors Promoted by Gate-Keeper Mutations in EGFR-Driven Lung Adenocarcinoma - Antonio MARAVER, Cancer Research Institute of Montpellier
