Programme scientifique
Preliminary program
Wednesday 23rd November - 4 parallel workshops:
Wednesday 23rd November, parallel session organized by Axis 1 - Cell Signaling and Therapeutic Targets
- 14h - 16h : New therapeutic targets of signaling pathways
Chairs: Karine Durand & Stéphane Pyronnet
- KEYNOTE SPEAKER: Stephan VAGNER, Institut Curie, CNRS UMR3348 (Paris) - Lecture: RNA binding proteins in the resistance to anti-cancer targeted therapies
- Pierre MARTINEAU, Cancer Research Institute of Montpellier - Targeting post-translational modifications in live cells using intrabodies
- Adrien GUERARD, Institute of Pharmacology and Structural Biology (Toulouse) - The medullary adipocytes contribute to the bone metastasis of prostate cancer and this effect is regulated by obesity
- Damien PLANCHON, Cell Biology Research Center of Montpellier - Overexpressed flotillins, new markers of metastatic development, promote cellular invasion by disrupting cadherin-mediated adhesion and stimulating extracellular matrix degradation
- Marc POIROT, Cancer Research Center of Toulouse - How the identification of an off-target of the antitumor drug tamoxifen led to the discovery of dendrogenin A: a tumor suppressor metabolite
- Julie GIRAUD, Bordeaux Research in Translational Oncology, INSERM U1053 - Deciphering and targeting YAP/TAZ activity in human gastric adenocarcinomas
- 16h30 - 18h30: SUNRiSE: Tools and models to study cancer stem cells
Chairs: Lucie Karayan-Tapon & Julie Pannequin
- KEYNOTE SPEAKER: Marc VAN DE WETERING, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences & Princess Maxima Center for Pediatric Oncology (Utrecht) - Lecture: Building cancer in organoids
- Christine VARON, Bordeaux Research in Translational Oncology, INSERM U1053 - Mouse models for the characterization and targeting of cancer stem cells in gastric adenocarcinoma
- Damien GREGOIRE, Institute of Molecular Genetics of Montpellier - Lineage tracing to study cancer stem cells in hepatocellular carcinoma
- Emmanuelle CHARAFE-JAUFFRET, Cancer Research Center of Marseille - PDX models to drive CSC personalized medicine
Wednesday 23rd November, parallel session organized by Axis 2 - Genome Dynamics and Cancer
- 14h - 16h : Genomic instability and cancer
Chairs: Kerstin Bystricky & Eric Julien
- Chen-Chun PAI, CRUK-MRC Oxford Institute for Radiation Oncology - Targeting histone H3K36me3-deficient cancers: lessons from yeast
- Etienne SCHWOB, Institute of Molecular Genetics of Montpellier - Towards chromosome replication profiling of tumour cells
- Thomas CLOUAIRE, LBCMCP, Center for Integrative Biology of Toulouse - Deciphering the chromatin landscape at DNA double strand breaks
- Lucile DELESPAUL, Actions for onCogenesis understanding and Target Identification in ONcology, INSERM U1218 (Bordeaux) - Recurrent TRIO fusion in non-translocation-related sarcomas
- Christophe GROSSET, Biotherapy of genetic diseases, inflammatory disorders and cancer, INSERM U1035 (Bordeaux) - "Bench-to-Bed" development of microRNAs for the treatment of adult and pediatric liver cancers
- 16h30 - 18h30: Chromatin dynamics and cancer
Chairs: Jérôme Dejardin & Martin Teichmann
- KEYNOTE SPEAKER: Laszlo TORA, Institute of Genetics and Molecular and Cellular Biology (Illkirch) - Lecture: Coactivator complexes and PIC components have two dynamic populations defined by active transcription and H3K4me3-ion
- Luisa DI STEFANO, LBCMCP, Center for Integrative Biology of Toulouse - The role of LSD1 demethylating complexes in vivo
- Thomas GERMIER, Laboratory of Eukaryotic Molecular Biology, Center for Integrative Biology of Toulouse - Chromatin dynamics of estrogen-regulated genes associated with transcription
- Marco BRUSCHI, Institute for Functional Genomics (Montpellier) - DNA Methylation Dynamics and its functional impact during the early stages of intestinal tumorigenesis
- Nour GHAZZAUI, Control of the B cell Immune Response and Lymphoproliferations (Limoges) - Role of the 3' regulatory region (3'RR) in the epigenetic control of the IgH locus during class switch recombination
Mercredi 23 et Jeudi 24 Novembre, session parallèle sur les organisations de santé organisée par Axe 4 - Cancer, enjeux individuels et collectifs
Mercredi 23 Novembre
- 14h - 16h : Organisations de santé | Evolutions du système de santé: dynamiques globales et spécificités de la cancérologie Modération: Béatrice Jacques
- ORATEUR INVITE: Daniel BENAMOUZIG, UMR CNRS 7116 CSO - Centre de sociologie des organisations et AVIESAN (Paris) - Conférence: Evolutions des organisations de santé en France
- Table ronde avec Jérôme VIGUIER, Institut national du Cancer (Paris), Jean-Marie BRUGERON directeur adjoint de l'ICM (Montpellier) et Jean-Marc PEREZ directeur adjoint de l'IUCT-Oncopôle (Toulouse)
- 16h30 - 18h30: Organisations de santé | plan cancer et évaluation des politiques de santé
- Table ronde avec :
Modération: Pascale Grosclaude
- Hélène GRANDJEAN, Haut comité de santé publique (Toulouse)
- Nadine HASCHAR NOE, EA 7419 - Centre de Recherche Sciences Sociales Sports et Corps (Toulouse)
- Audrey VEZIAN, UMR CNRS 7116 - Centre de sociologie des organisations (Paris)
Jeudi 24 Novembre
- 8h30 - 10h: Organisations de santé | les soins de support
Modération: Eric Bauvin
- Pierre SENESSE, Institut régional de Cancérologie de Montpellier - Les soins de support en oncologie: une révolution en marche
- Nathalie CAUNES, Institut Claudius Régaud-Oncopôle (Toulouse) - DISSPO pour les soins de support? L'évolution organisationnelle des soins de support en département au sein de l'IUCT
- Philippe TERRAL, EA 7419 - Centre de Recherche Sciences Sociales Sports et Corps (Toulouse) - Impliquer des patients dans la co-construction d’un programme d’éducation thérapeutique au sein d’ateliers coordonnés par une unité de soins de support : Quelle(s) expertise(s) d’usage mobiliser ?
- Grégory NINOT, EA 4556 Epsylon - Dynamique des capacités humaines et des Conduites de santé (Montpellier) - Sortir de l’ambiguïté sur l’activité physique dans les soins de support
- 10h30 - 12h: Organisations de santé | les réseaux de cancérologie
Modération: Philippe Gorry
- Isabelle KLEIN, Oncolor - réseau régional de cancérologie de Lorraine (Nancy) - Le fonctionnement d'un réseau dans son contexte. L'exemple d'Oncolor
- table ronde avec
- Philippe VAGNER, ARS (Montpellier)
- Eric BAUVIN, ONCOMIP - réseau régional de cancérologie de Midi-Pyrénées (Toulouse)
- 14h - 16h: Sciences Humaines et Sociales, épidémiologie et santé publique
Présentations flash de posters sur toutes les thématiques de l'axe 4
Wednesday 23rd November, parallel session organized by Axis 5 - Health technologies
- 14h - 16h : Micro devices for cancer
Chair: Anne-Marie Gué
- KEYNOTE SPEAKER: Andrew GRIFFITHS, ESPCI Paris Tech - Lecture: Ultra-High-Throughput Su=ingle-Cell Genotyping and Phenotyping using Droplet-Based Microfluidics
- Pierre NASSOY, Institut d'Optique Graduate School (Bordeaux) - The Cellular Technology: a route towards realistic tumor models
- Manouk ABKARIAN, Structural Biology Center (Montpellier) - A new look at blood shear-thinning
- Jean CACHEUX, LAAS-CNRS (Toulouse) - Circulating microRNA detection using fluorescence-based nanofluidic platform for the early diagnosis of pancreatic cancer
- Dominique PAGNOUX, XLim (Limoges) - Polarimetric imaging technique through an optical fiber: towards an endoscopic tool for the diagnosis of cancers of inner cells
- 16h30 - 18h30: Technology transfer and innovation
Chair: Guy Kantor
- Marie MAYNADIER, NanoMedSyn (Montpellier) - NanoMedSyn: a new platform for therapeutic targeting: Glyco-Nano-Vectors
- Aurélien BANCAUD, LAAS-CNRS (Toulouse) - High sensitivity detection of DNA with microfluidics: transfer of a technology dedicated to the profiling of circulating DNA
- Marc VERELST, ChromaLys (Toulouse) - ChromaLys and its Tumor-Track Project
- Sabrina SERPILLON, Kyomed (Montpellier) - How to facilitate the clinical validation of medical devices and biomarkers in the era of e-health ?
- KEYNOTE SPEAKER: Pascal RAGOUET, University of Bordeaux - Lecture: Une sociologie de la recherche translationnelle? Esquisse d'un programme
Thursday 24th November - 4 parallel workshops:
Thursday 24th November, parallel session organized by Axis 1 - Cell Signaling and Therapeutic Targets and Axis 2 - Genome Dynamics and Cancer
- 8h30 - 10h : Transcriptional control in cancer
Chairs: Daniel Fisher & Martin Teichmann
- KEYNOTE SPEAKER: Martin EILERS, Theodor Boveri Institute and Comprehensive Cancer Center Mainfranken, Biocenter, University of Würzburg - Lecture: Transcriptional control and transformation by MYC proteins
- Didier TROUCHE, LBCMCP, Center for Integrative Biology of Toulouse - The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
- Sandrine FAURE, Physiology and Experimental Medicine of Heart and Muscles (Montpellier) - The RNA-binding protein LIX1 controls the proliferation of stomach mesenchymal progenitors and GastroIntestinal Stromal Tumor (GIST) cells
- Stéphan JALAGUIER, Cancer Research Institute of Montpellier - Interplays between RIP140 and LCoR transcription factors in breast cancer cells
- 10h30 - 12h: Transcription-translation crosstalk in cancer
Chair: Stéphane Pyronnet
- KEYNOTE SPEAKER: Victoria COWLING, Center for Gene Regulation and Expression (Dundee) - Lecture: mRNA capping in transcription and translation
- Alexandre DAVID, Institute for Functional Genomics (Montpellier) - Epitranscriptome plasticity in colorectal cancer
- Marta KWAPISZ, LBCMCP, Center for Integrative Biology of Toulouse - The role of non-coding transcription in regulation of rDNA chromatin state
- Jean-Marie PELOPONESE, Center for studies of Pathogens and Biotechnologies for Health (Montpellier) - HBZ-mediated shift of JunD from growth suppressor to tumor promoter by inhibition of ribosomal protein S25 expression
- 14h - 16h: Translational control in cancer
Chairs: Estelle Espinos & Julie Pannequin
- KEYNOTE SPEAKER: Owen SANSOM, The Beatson Institute for Cancer Research (Glasgow) - Lecture: Translational control of colorectal cancer
- Anne CAMMAS, Cancer Research Center of Toulouse - Mechanisms of translational control by RNA structures and RNA binding proteins in cancer
- Frédéric SALTEL, Bordeaux Research in Translational Oncology, INSERM U1053 - Active mRNA translation into invadosomes revealed by combination of laser capture and proteomic analysis
- David MULLER, Cancer Research Center of Toulouse - Loss of 4E-BP1-mediated translational control favors aberrant replication in pancreatic cancer
- Jean-Philippe COMBIER, Plant Research Laboratory, UMR 5546 CNRS-UPS (Toulouse) - Primary transcripts of microRNAs encode regulatory peptide
Thursday 24th November, parallel session organized by Axis 3 - Translational Research, from Biology to Clinical Research
- 8h30 - 10h : Translational research: Emerging projects
Chair: Nadine Houédé
- Franck COUILLAUD, Molecular Imaging and Innovative Therapies in Oncology (Bordeaux) - In vivo imaging of gene expression induced by magnetic hyperthermia
- Diego TOSI, Cancer Research Institute of Montpellier - Characterisation of chemotherapy effect on colorectal cancer cell phosphokinome
- Charline OGIER, Cancer Research Institute of Montpellier - Blockade of the Neuregulin/HER3 axis to inhibit the crosstalk between CAF and tumor cells : a promising therapeutic option in pancreatic cancer
- Laura RODRIGUES, Angiogenesis and Tumor Microenvironment Laboratory & The Laboratory of Organic Polymer Chemistry (Bordeaux) - Design and self-assembly of CXCR3-targeting block copolymer nanoparticles
- 10h30 - 12h: Translational Research in Colorectal Cancer Treatment
Chair: Marc Ychou
- KEYNOTE SPEAKER: Christophe BORG, University Hospital of Besançon & Inserm U1098 - Lecture: The immune system, a double edge sword during colon cancer oncogenesis
- Nicole TUBIANA, University Hospital of Limoges, Litaty MBATCHI, University Hospital of Nîmes & Cancer Research Institute of Montpellier, Maguy DEL RIO, Cancer Research Institute of Montpellier - BIOCOLON : translational research assay in metastatic colon cancer, from clinic to basic research
- Christel DEVAUD, Digestive Health Research Institute (Toulouse) - Immune microenvironment drives colorectal cancer fate
- Abdel-Majid KHATIB, Angiogenesis and Tumor Microenvironment Laboratory (Bordeaux) - Virtual ligand screening identifies the proprotein convertase small molecule inhibitors as new potential colorectal liver metastases therapy
- 14h - 16h: Molecular oncology and personalized medicine
Chair: Alexandre Evrard
- KEYNOTE SPEAKER: Pierre LAURENT-PUIG, Georges Pompidou European Hospital & UMR-S 1147 (Paris) - Lecture: Molecular oncology and personalized medicine : the exemple of colorectal cancer
- Olivier CALVAYRAC, Cancer Research Center of Toulouse - The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in NSCLC via an AKT-dependant mechanism
- Brice PASTOR, Cancer Research Institute of Montpellier - Clinical utility of longitudinal plasma analysis in examining clonal evolution and tracking secondary acquired resistance in mCRC patients refractory to targeted therapy
- David PIQUEMAL, Acobiom (Montpellier) - Patient Stratification and Precision Medicine in Pancreatic cancer: a gene blood-signature for gemcitabine treatment
- Richard IGGO, Bergonié Institute (Bordeaux) - The mammary ducts create a favourable microenvironment for xenografting of luminal and molecular apocrine breast tumours
Thursday 24th November, parallel session organized by Axis 5 - Health Technologies and Clinical and In Vivo Imaging Club
- 8h30 - 10h : Nanotools for therapy and diagnosis
Chair: Jean-Pierre Pouget
- KEYNOTE SPEAKER: Marc JANIER, University Hospital (Lyon) - Lecture: Theranostic, How to couple diagnosis by imaging with treatment
- Frédéric FRISCOURT, Aquitaine Institute for Cognitive and Integrative Neuroscience (Bordeaux) - The sweet imaging of cancer
- Nadir BETTACHE, Max Mousseron Biomolecules Institute (Montpellier) - Nanoparticles for cancer theranostic: targeting, imaging and photodynamic therapy
- Alexandre PICHARD, Cancer Research Institute of Montpellier - 177Lu-lilotomab versus 177Lu-rituximab in antibody radioneclide conjugate therapy of Non-Hodgkin lymphoma: a radiobiological approach
- 10h30 - 12h: Magnetic Resonance Imaging for diagnosis and therapy of cancer
Chair: Olivier Sandre
- KEYNOTE SPEAKER: Claire BILLOTEY, Therapeutical Targeting in Oncology (Lyon) - Lecture: MRI and Nanoparticles: A tandem business
- Yannick GUARI, Charles Gerhardt Institute (Montpellier) - Coordination polymers nanoparticles as contrast agents for MRI and SPECT
- Paul MATHIEU, Coordination Chemistry Laboratory (Toulouse) - Design of a nanostructured MRI contrast agent
- Jonathan PAGE, Intense Lasers and Applications Center (Bordeaux) - Entropic Boltzmann closure for radiotherapy
- 14h - 16h: Delivery and toxicity of nanodrugs
Chair: Muriel Golzio
- KEYNOTE SPEAKER: Jean-Luc COLL, INSERM 1209 - University of Grenoble Alpes - Lecture: Defining remotely activatable nanovectors and instrumentations for cancer diagnostics and therapy
- Audrey FERRAND, Digestive Health Research Institute (Toulouse) - Multimodal nanoparticles for tumor detection and tracking during radiotherapy
- Riad LADJOHOUNLOU, Cancer Research Institute of Montpellier - Involvement of targeted and non-targeted effects during alpha or Auger RIT of small volume peritoneal carcinomatosis
- Hamideh SALEHI, Bioengineering and Nanosciences Laboratory (Montpellier) - Confocal Raman microscopy for tracing oxaphosphinanes (phostines) in glioblastom, non epithelial (SNB75)
Friday 25th November
- 8h30 - 10h30: Making sense of (big) data
Chairs: Jacques Colinge & Daniel Fisher
- KEYNOTE SPEAKER: Allan BRADLEY, Wellome Trust Sanger Institute (Hinxton) - Lecture: Humanizing the mouse immune repertoire for Therapeutic antibody discovery
- Jacques COLINGE, Cancer Research Institute of Montpellier - Large, complex, and rich data sets: the need for "coordinate systems" and imagination
- Fabien PIERRAT, Acobiom (Montpellier) - The MARS (Matrix of RNA-Seq) viewer project
- Jean-Jacques FOURNIE, Cancer Research Center of Toulouse - Stratifying Patients for Immune Checkpoint Blockade Cancer Therapies
- Sébastien ORAZIO, Registre général des cancers de la Gironde (Bordeaux) - Personal medical data linking: Development and validation of a reliable and easy-to-use software tool.
- 11h15 - 12h45: organized in collaboration with SIRIC Montpellier Cancer
- Pre-clinical models
Chairs: Claude Sardet & Charles Theillet
- Valérie LOBJOIS, Advanced Technology Institute in Life Sciences (Toulouse) - Tumor cell proliferation and organization dynamics in 3D
- Charles THEILLET, Cancer Research Institute of Montpellier - PDX models, why, how and for what aim?
- Lucile THOUENNON, Cancer Research Institute of Montpellier - MPCC platform: preclinical models of digestive cancers
- Le Grand Défi Vivez Bougez
Chair: Florence Cousson-Gélie
- Mathieu GOURLAN, Epidaure, Montpellier Cancer Institute & Epsylon Laboratory - The Great Live and Move Challenge: Impact and mediating mechanisms of a physical activity intervention implemented among children
- 14h - 16h: New concepts in Oncogenesis
Chairs: Urszula Hibner & Gilles Favre
- KEYNOTE SPEAKER: Cédric BLANPAIN, WELBIO, Interdisciplinary Research Institute, Université Libre de Bruxelles - Lecture: Cancer cell of origin and tumor heterogeneity
- Magali SUZANNE, Center for Integrative Biology of Toulouse - How does apoptosis influence tissue tension?
- Michael HOCHBERG, Institute of Evolutionary Sciences (Montpellier) - The evolutionary theory of cancer resistance and how anthropogenic impacts contribute to cancers across animal species and in humans
- Laurent GROS, Cancer Research Institute of Montpellier -Characterization of long-term protective immunity after antitumor-based monoclonal antibody immunotherapy in melanoma
- Philippe PASERO, Institute of Human Genetics (Montpellier) - SAMHD1 acts at stalled replication forks to prevent ssDNA-mediated induction of type I interferons
