Programme final disponible
Le Cancéropôle GSO et le SIRIC Montpellier Cancer vous convient au workshop "New mass spectrometry approaches to study cancer genome functions and beyond" qui se déroulera le 13 décembre 2018 à Montpellier.
PROGRAMME FINAL>>
ANNONCE >>
Inscriptions
Le workshop est gratuit mais l'inscription obligatoire>> (nombre de places limitées). Date limite : 30 novembre 2018.
Lieu : Salle de conférence de l'Institut de Recherche en Cancérologie de Montpellier (accès>>)
Contexte scientifique
A côté des approches de séquençage d'ADN à grande échelle, la protéomique et les analyses par spectrométrie de masse (MS) deviennent essentielles dans l'étude des fonctions du génome, notamment pour appréhender l'écosystème tumoral. Il est ainsi possible d'étudier l'impact biochimique des anomalies génétiques liées au cancer, par une quantification précise et ciblée des protéines et de leurs formes modifiées et variantes. Par exemple, en comparant les échantillons de personnes en bonne santé et de personnes malades, les analyses MS conduisent à découvrir et valider l'utilisation de biomarqueurs et de différents paramètres biologiques mesurables, permettant ainsi de diagnostiquer ou de suivre l'évolution de la maladie.
Bien qu'en plein essor, les approches protéomiques et spectrométrie de masse restent difficiles et présentent de nombreux challenges technologiques qu'il est important d'appréhender. Dans ce contexte, des spécialistes reconnus partageront leur expertise et des projets initiés au sein du Cancéropôle GSO et du SIRIC Montpellier Cancer seront présentés et discutés. La journée vise ainsi à présenter à la communauté scientifique quelques projets déjà en cours et permettre le partage d'expertises et outils sur les approches de protéomique et autres analyses par MS autour en particulier de l'analyse de la structure et des fonctions du génome.
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)